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About

xArchive 3D Bioprinting Core at IUSM


 

References:

  1. Smith LJ, Li P, Holland MR, Ekser B. FABRICA: A Bioreactor Platform for Printing, Perfusing, Observing, & Stimulating 3D Tissues. Sci Rep. 2018;8(1):7561. Published 2018 May 15. doi:10.1038/s41598-018-25663-7
  2. Sego TJ, Prideaux M, Sterner J, et al. Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models. Biotechnol Bioeng. 2020;117(3):798‐815. doi:10.1002/bit.27238
  3. Chen AM, Lashmet M, Isidan A, et al. Oxygenation Profiles of Human Blood, Cell Culture Medium, and Water for Perfusion of 3D-Bioprinted Tissues using the FABRICA Bioreactor Platform. Sci Rep. 2020;10(1):7237. Published 2020 Apr 29. doi:10.1038/s41598-020-64256-1
     

Core Highlights and Accomplishments

We have a well-designed workflow for users to turn their 2D cultures into 3D tissue models that best approximate in situ conditions. Our Core features:

  • The State-of-the-Art Regenova Bio 3D Printer which prints tissues in 3D
  • The Patent-Pending FABRICA Bioreactor Platform which provides oxygenated perfusion to bioprinted tissues at controlled rates.
    • Our platform has been flow characterized ultrasonically and through computational fluid dynamics so we can achieve in vivo-like tissue culture conditions.
  • A Patent-Pending Microtissue Platform for making large volumes of spheroids for 3D bioprinting
    • Our entire platform integrates directly with cell culture incubators and can be modified to suit user needs.

We have already generated or investigated tissues ranging:

  • Bone
  • Liver
  • Reproductive tissue
  • Cornea

Some of which resulted in our research has being published in the following journals:

  • Scientific Reports
  • Biotechnology and Bioengineering
  • Bioprinting
  • Xenotranplantation
  • Current Opinion in Organ Transplantation

Which has led to prestigious awards including:

  • American Society for Transplant Surgeons: Vanguard Award
  • Orthopaedic Research Society: Alice L. Jee Award

Our research collaborations spans the IU community, including:

  • Radiology and Imaging Sciences
  • Transplant Surgery
  • Anatomy and Cell Biology
  • Mechanical Engineering
  • Biomedical Engineering
  • The Cancer Center

 

Leadership

Lester Smith, PhD

Core Director

smitlej@iu.edu

Location and hours of operation

Hours Location

Monday-Friday

9:00 am-5:00 pm

Or By Appointment

Walther Hall, R3-C343

980 W. Walnut

Indianapolis, IN 46202

 

Links and Resources

  1. https://medicine.iu.edu/radiology/research/bioprinting
  2. https://www.ncbi.nlm.nih.gov/pubmed/?term=super+tissue+sego+smith
  3. https://www.ncbi.nlm.nih.gov/pubmed/29765087

Contacts

Name Role Phone Email Location
Lester Smith, PhD
Core Director
 
317-278-8057
 
smitlej@iu.edu
 
R2 E180
 

Service list


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