ALERT

ATTENTION ⚠️

In observance of the holiday, Juneteenth, Agilent CrossLab/iLab Operations Software Support Help Desk will be closed during U.S. hours on Thursday, June 19th, 2025. We will resume regular U.S. support hours on Friday, June 20th, 2025. EU and APAC Support will remain open during this time. For urgent matters, please add "Urgent" to the ticket/email subject or press "1" when prompted to escalate a call on the iLab Support phone, and we will prioritize those requests first.

ALERT

Pls. ensure to update any @iupui.edu email addresses within your user account, core account, etc. profile to reflect @iu.edu, per IU's One Mail project. 

Solutions for many iLab inquiries may be found on the IU iLab FAQ page.  Should further assistance be needed, contact iLab support via ilab-support@agilent.com.  The Agilent iLab Help Resources Hub is also a useful page.

(hide this warning on this page)
About

xArchive 3D Bioprinting Core at IUSM


 

References:

  1. Smith LJ, Li P, Holland MR, Ekser B. FABRICA: A Bioreactor Platform for Printing, Perfusing, Observing, & Stimulating 3D Tissues. Sci Rep. 2018;8(1):7561. Published 2018 May 15. doi:10.1038/s41598-018-25663-7
  2. Sego TJ, Prideaux M, Sterner J, et al. Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models. Biotechnol Bioeng. 2020;117(3):798‐815. doi:10.1002/bit.27238
  3. Chen AM, Lashmet M, Isidan A, et al. Oxygenation Profiles of Human Blood, Cell Culture Medium, and Water for Perfusion of 3D-Bioprinted Tissues using the FABRICA Bioreactor Platform. Sci Rep. 2020;10(1):7237. Published 2020 Apr 29. doi:10.1038/s41598-020-64256-1
     

Core Highlights and Accomplishments

We have a well-designed workflow for users to turn their 2D cultures into 3D tissue models that best approximate in situ conditions. Our Core features:

  • The State-of-the-Art Regenova Bio 3D Printer which prints tissues in 3D
  • The Patent-Pending FABRICA Bioreactor Platform which provides oxygenated perfusion to bioprinted tissues at controlled rates.
    • Our platform has been flow characterized ultrasonically and through computational fluid dynamics so we can achieve in vivo-like tissue culture conditions.
  • A Patent-Pending Microtissue Platform for making large volumes of spheroids for 3D bioprinting
    • Our entire platform integrates directly with cell culture incubators and can be modified to suit user needs.

We have already generated or investigated tissues ranging:

  • Bone
  • Liver
  • Reproductive tissue
  • Cornea

Some of which resulted in our research has being published in the following journals:

  • Scientific Reports
  • Biotechnology and Bioengineering
  • Bioprinting
  • Xenotranplantation
  • Current Opinion in Organ Transplantation

Which has led to prestigious awards including:

  • American Society for Transplant Surgeons: Vanguard Award
  • Orthopaedic Research Society: Alice L. Jee Award

Our research collaborations spans the IU community, including:

  • Radiology and Imaging Sciences
  • Transplant Surgery
  • Anatomy and Cell Biology
  • Mechanical Engineering
  • Biomedical Engineering
  • The Cancer Center

 

Leadership

Lester Smith, PhD

Core Director

smitlej@iu.edu

Location and hours of operation

Hours Location

Monday-Friday

9:00 am-5:00 pm

Or By Appointment

Walther Hall, R3-C343

980 W. Walnut

Indianapolis, IN 46202

 

Links and Resources

  1. https://medicine.iu.edu/radiology/research/bioprinting
  2. https://www.ncbi.nlm.nih.gov/pubmed/?term=super+tissue+sego+smith
  3. https://www.ncbi.nlm.nih.gov/pubmed/29765087

Contacts

Name Role Phone Email Location
Lester Smith, PhD
Core Director
 
317-278-8057
 
smitlej@iu.edu
 
R2 E180
 

Service list


Search available services: View: by category alphabetically
► FABRICA (2)
► Kenzan (9)
► Miscellaneous (5)

Map